A malignant pustule is a type of cutaneous infection associated with Anthrax. When first contact is established, the skin forms a papule, or small, round bump, raised on the surface. The papule then turns into a vesicle, a raised cell with a sac or bubble. Once the vesicle bursts, toxins from the anthrax release and cause many severe medical conditions. Septicemia, or infection of the blood, sets in and can cause organ failure. Additionally, high fever, vomiting, and severe sweating are associated with this infection. The contagion usually results in death.