A central theme to Are You There, God? It's Me, Margaret is coming of age. In this Judy Blume novel for young teens, the protagonist Margaret struggles with her identity, growing up, puberty, and adjusting to the sixth grade. Blume uses humor throughout the novel to diffuse the difficulty of real life situations that preteen girls face--especially in the way that their bodies are developing and changing; from worrying about wearing bras to getting her period, Margaret's anxiety often is tempered by Blume poking fun at the issues. Are You There, God? It's Me, Margaret exposes practically every major concern and worry that young adults face, and by Blume addressing the issues through humor, the author gently acknowledges that these are problems that every young person has dealt with and overcome.