I suppose that different readers might choose slightly different "main" conflicts in the story. I'll highlight a few of the major conflicts that are present in Unwind.
For me, the most central conflict in the story is a person/people vs. society conflict. Shusterman has created a world in which retroactive abortion is acceptable. The population has bought into the idea that a child's life doesn't end if his/her body parts are farmed out and donated to other people. This process of harvesting teenage body parts is called "unwinding."
However, between the ages of thirteen and eighteen, a parent may choose to retroactively "abort" a child . . .
. . . on the condition that the child's life doesn't "technically" end.
The process by which a child is both terminated and yet kept alive is called "unwinding."
Connor, Risa, and many other characters in the book have all been labelled for unwinding, and they don't want that to happen. They know that unwinding is a lie, and they know that they...
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