What is the significance of this quote from Macbeth?" "Yet do I fear thy nature - it is too full o' the milk of human kindness to catch the nearest way" (I,v,16–17).

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This quote establishes Lady Macbeth's own ruthless nature and helps foreshadow the later role she would play in the eventual murder of Duncan, castigating and shaming Macbeth when he suffers a crisis of conscience to ensure that he goes through with the plot. In the process, it establishes an impression of Lady Macbeth's relationship with her husband as being (by all accounts) the more ruthless of the two, at least in this part of the play.

However, what I find particularly interesting is the question of how this statement fits into Macbeth's larger plot, particularly as it involves Macbeth's deterioration into a bloodthirsty tyrant. After all, as we proceed further into the play, we notice that Macbeth's rule has a deeply sanguinary nature. In a way, I think Macbeth is a deeply psychological play, one which examines how this act of murder affects its perpetrators. We see this reflected in Lady Macbeth's later madness and suicide brought on by guilt, and I think we see this in the bloodthirsty tyranny of Macbeth himself. Thus, when seen within that context, this statement helps to establish an initial impression of Macbeth that this later characterization can be contrasted against. Thus it suggests the degree to which Macbeth himself has fallen, as he twists himself into a monster.

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In act 1, scene 5, Lady Macbeth reads her husband's letter, which describes his interaction with the Three Witches and mentions that they predicted he would become the future king of Scotland. After reading the letter, Lady Macbeth believes that her husband could eventually become king but fears that he is too kind to take the necessary steps to attain the position. Lady Macbeth says,

"Yet do I fear thy nature; It is too full o' th' milk of human kindness To catch the nearest way." (1.5.3-5)

Lady Macbeth is essentially saying that she is worried that Macbeth is too sensitive and compassionate to strike aggressively at his first opportunity to usurp power. Lady Macbeth believes that her husband lacks the callous nature needed to carry out her wicked plan. Later on in the play, Lady Macbeth convinces her husband to assassinate King Duncan and even participates in the murder. Following King Duncan's assassination, Macbeth gradually becomes a ruthless, bloodthirsty tyrant, who is willing to murder anyone threatening his position as king.

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This quote comes from Act I, Scene V and is significant because it reveals much about Lady Macbeth's character and the relationship she has with her husband. Firstly, by stating that Macbeth is full of the "milk of human kindness," Lady Macbeth argues that her husband is naturally a kind and gentle person—so much so that he cannot "catch the nearest way" (to take what he wants through force).

By making this judgment about her husband, Lady Macbeth reveals an important trait of her own: that she is the natural leader in their marriage. She knows that she must take charge of this situation, or else Macbeth will lose his chance to be king. In other words, it is down to her to make sure that this natural kindness is replaced by ambition and violence, traits which she has in abundance.

Through this quote, Shakespeare inverts the natural order. Instead of adopting the traditional masculine and feminine roles, the roles of Macbeth and Lady Macbeth are reversed. It is she who leads the way, and it is he who will follow.

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Lady Macbeth says this line immediately after reading a letter she has just received from her husband.  In that letter, Macbeth informs his wife that the witches have prophesied that he will be King.  He is telling Lady Macbeth the news so that she might share in the joy that the prophesy has brought him, saying,

"This have I thought good to deliver thee my dearest partner of greatness, that thou mightst not lose the dues of rejoicing by being ignorant of what greatness is promised thee...Lay it to thy heart..." (I,v,10-13).

Lady Macbeth is indeed overjoyed, and in her excitement she reveals herself to be an extremely ambitious and unscrupulous woman.  Her first inclination is to take things into her own hands, doing whatever it might take to make the prophesy come true, and come true as quickly as possible.  To this end, she schemes to do away with Duncan, the current King, but she is afraid that Macbeth, although ambitious, is not as ruthless as she is.  She is afraid that he is too kind by nature to do what needs to be done so that he can be King right away, and she voices her concern, saying,

"Yet do I fear thy nature, it is too full o' the milk of human kindness to catch the nearest way.  Thou wouldst be great, art not without ambition, but without the illness should attend it" (I,v,16-20).

Lady Macbeth knows her husband is ambitious, but she is afraid he doesn't have the "illness", or the unscrupulous disregard for goodness, to act heinously and kill Duncan to gain the crown for himself.

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