In So Far From God, Ana Castillo blends the supernatural with a realistic social critique of injustices on many levels of society. The novel centers on Sofia and her four daughters, and each of these women experiences social injustice in some fashion, making them representative of the many people who struggle through life. Let's look at some examples.

One of the daughters, Fe, longs for the American dream. She marries a man and seems to have the perfect middle-class life. They have a nice house and a new car and all the amenities that society expects people to have. But there is a catch. To support that lifestyle, Fe goes to work in a chemical company where she ends up poisoned by the chemicals. Herein lies a comment on the lengths to which people must go to meet society's expectations, as well as the revelation of the severe pollution that is let loose in the world.

Another daughter, Esperanza, becomes a journalist. She is committed to social activism and to reporting the injustices she sees all around her. But when she is assigned to report on the Persian Gulf War, she never comes home. The injustice has caught up with her.

Yet another daughter, Caridad, reveals the exploitation of women when she is rejected by her boyfriend and enters into a pattern of alcoholism and sex. She is eventually attacked, and later in the novel, she is stalked by a man who wants to marry her. In the end, Caridad commits suicide in order to escape him.