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star-cross'd means that the stars were not favorable to the lovers.

At the time Shakespeare lived, any ill-fated venture was considered "not in the stars".  The romance between Romeo and Juliet was certainly ill-fated.

The paradoxical theme of love and death, as announced in the Prologue , indicates the fate...

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star-cross'd means that the stars were not favorable to the lovers.

At the time Shakespeare lived, any ill-fated venture was considered "not in the stars".  The romance between Romeo and Juliet was certainly ill-fated.

The paradoxical theme of love and death, as announced in the Prologue, indicates the fate of the lovers with such words as “star-crossed,” “fatal loins,” and “death-marked love.” (http://www.enotes.com/romeo/act-scenes-1-2-summary-analysis)

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