What innate human responses are most signs of deception based upon?
Your question is a little vague. I'll try to be useful however. One human response that underlies signs of deception is the human response of self-preservation. Deception is aimed at protective and preserving behavior. Thus when a lying person desplays avoidance techniques that aim to control and manipulate what they believe to be physical "tells" of deception, the human response underlying this is protection and self-preservation.
Another human response that underlies signs of deception is comprised of physiological refelx actions, such as gaze aversion, looking up and to the left, fidgeting, gesturing, facial expressions and changes to physiological markers (pulse, heart rate , perspiration etc). When these are missing, the likelihood of deception increases. This control and manipulation of physiological actions is also based upon self-preservationa nd protection. (FBI)