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This famous sermon is the most famous sermon delivered by Jonathan Edwards, which he preached on a visit to the congregation at Enfield, Connecticut, in 1741. The sermon is of course shaped by his audience, and the "natural men" he challenges were those in the congregation who had not yet made a commitment to Jesus Christ, or had been "born again." One of the reasons why this sermon was so famous was that it had such a powerful impact on his audience. Several times he had to halt his delivery and ask his audience to refrain from shrieking and swooning, so powerful was his oration. I have provided the link to the enotes section of this group below that should be able to fill in more information regarding the content and themes of this sermon.