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The Renaissance was a period of revolutionary change in so many areas, the first thing you need to do is determine what area you want to address in your thesis. It would be possible to develop an essay regarding the changes brought about during the Renaissance in many areas of endeavor.
If I were writing the essay, I would argue that the most far-reaching change of all during the Renaissance period was the invention of the printing press as perfected by Johannes Gutenberg. I would support that thesis by demonstrating the impact that the comparative mass production of printed materials, in contrast to the hand-written copies that were all that was available prior to that time, changed European cultures in many and radical ways.
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