This is a very open ended requests. There are many different ways to read the novel and so many different things to say. That said, one of the central themes of the novel is the drive for excess.
Victor's pursuit of knowledge was excessive. He wanted it too badly, and so he pushed the limits and created a new being. In the end, he transgressed human boundaries, and it had disastrous consequences. All those he loved died.
The Greeks used to say something wise - "nothing in excess." They knew that there was a certain boundary that should not be crossed. Victor did not have this check. We can also that Robert Walton was the same. He wanted to reach the North Pole. This too was rooted in excessive pride. It nearly killed him, but he fortunately came to his senses.
Please keep in mind that this is only one theme. There are many others.