Formal analysis of Perugino's work centers on elements of note in the art work. One such element is the raising of Christ in the crucifixion. This vision of the crucifixion is not one where there is tremendous sadness. Formal analysis reveals how the artist designed the vision of crucifixion to be one in which he is "literally raised above human suffering." The manner in which the crucifixion, itself, is depicted is part of the formal analysis of Perugino's work.
Another such element in formal criticism of Perugino's vision rests in the collection of saints around him. The folded hands of Magdalene is shown to highlight her devotion to Christ. Along these lines, the collection of John the Baptist and the Virgin Mary and their facial expressions of transcendence are sources of analysis in the portrait. At the same time, the presence of trees and plant life in the background have been analyzed to represent how there is fruition and hope within the crucifixion. These are aspects of formal analysis of Perugino's work.