At the end of chapter 17, of Frankenstein, Victor is horrified by the idea that he must create another creature. Victor, sympathizing with the creture's story, agrees to create a mate. The creature promises to leave all lands inhabited by mankind if Victor will create a being he can love (and will love him in return).
At the end of the chapter, Victor describes to readers how he feels when facing the fact that he must create another creature.
These were wild and miserable thoughts; but I cannot describe to you how the eternal twinkling of the stars weighed upon me, and how I listened to every blast of wind as if it were a dull ugly siroc on its way to consume me.
Nature, here, is certainly "upset" with Victor. He knows that he has broken the natural order of things given he has created life (something, to this point, that only women could do). Given that the natural order of things has been broken, Victor feels as if nature itself will enact revenge upon him.
Therefore, the end of the chapter foreshadows Victor's correction of his wrong-doings. His statement regarding nature consuming him shows his recognition that he has thrown out the balance of nature. The only way to set nature right, for Victor, is to correct his mistakes.