Risk factors include major vascular catheterization, the presence of mechanical devices, burns, and intravenous injection of drugs.
Fungal infectionS occurs most often in immunocompromised patients with neutropenia, often after therapy with broad-spectrum antimicrobial agents. The extensive use Corticosteroids, of antimicrobial agents, of implanted catheters, of mechanical ventilation and mechanical devices also contributes to septicemia development.
I. Impaired Host Defenses, for e.g.
Deficiency of cell-mediated/ humoral immunity
Decreased complement level etc.
Diminished inflammatory response
Prematurity and low birth weight
Intravenous drug abuse
II. Pre-existing Infections
III. Instrumentation and Surgery Examples
IV. Other Factors Such as-difficult delivery, exposure to infected incubators, exposure to infected ventilators, etc.