Helmholtz, Bernard, Mond, and John all have one thing in common and that is intelligence. They all have different educational backgrounds and life experiences, but they are all isolated from society because of their intelects, ideas, and individualism. They all react differently to the knowledge that they have, too, and that leads them to represent different elements of the society in which they live. Helmholtz and Bernard are products of the cloning and are employed in keeping it running on a shallow-headed lifestyle. Helmholtz is more in control of his feelings than Bernard is. Bernard makes rash decisions on impulse and doesn't care who he hurts as long as his social status remains in tact. Helmholtz, on the other hand, seems to be a pretty kick-back guy who rolls with the punches. These two are caught in the middle of it all whereas John and Mond are on opposite extremes of the ideology presented.
Mond is the intellectual in control of everything, the defender of the common good, or what one might call "the Man." John is the outsider from another civilization, but also the voice from the past. Since John is greatly influenced by Native American beliefs and Shakespeare, he is the voice from our civilization in conflict with the that of the new; and at the end of the book when Mond and John debate the whole situation, it would seem that Mond and the new society wins over what we have and know today (i.e., monogamous relationships, religion).