I think that The Road by Cormac McCarthy is an excellent novel that addresses the universal themes of man's survival, religion, love, and the search for meaning in an often brutal society. The story also has geopolitical undertones relating to how mankind, by way of their governments, brings on more trouble than value to society because of the competitiveness and greed of nations as they deal with one another.
I also think that the novel highlights the love between parents and their children and how parents typically will sacrifice much to ensure the best for their children. This is exemplified greatly in "The Road" by the father. He constantly strives to get to the coast in the hopes that he and his son will find some relief and better physical sustenance than they currently have as they roam the burnt-out countryside.
From a purely literary standpoint, I love the structure of the novel and the way that Cormac McCarthy handles dialogue with simplicity and without the use of quotation marks. The novel flows effortlessly from scene to scene via the quality of the authors writing and unadorned, direct, and forceful style.
Cormac McCarthy draws the reader in with a compelling story that focuses on human survival. The story dramatically highlights how, amidst all of humankind's technological advancements, we are most likely on a course of annihilation unless we change the most important aspect of ourselves, our moral core, and develop a spirit of cooperation with one another.