The biggest disadvantage of industrialization is environmental. I always think of descriptions of London in the 19th century. A river of sludge, poisonous air, bodies in the streets and cramped, unsanitary working and living conditions. We are not always aware of what is in the air and water. We also don't know what's in the food we eat or the products we use. It's frightening!
Disadvantages of industrialization could be grouped into several major categories.
Ecological effects of industrialization include pollution of air, water, and soil. Industrialization has created and continues to create waste materials that need to be stored or disposed of, often creating further potential for harm of the natural environment. Industrialization has resulted in and is still causing the depletion of natural resources, sometimes with further ramifications for the environment.
The negative impact of industrialization upon humans can be measured in terms of lives shortened through accidents or illnesses resulting from work in industrial settings and by changes to the basic structure of family units caused by new patterns of work and home responsibilities.
Financially, industrialization has led to increasing separation between "haves" and "have nots", whether referring to individuals or countries. Those persons and countries who are benefiting from industrialization are consuming an increasing percentage of the world's resources, leaving those who are not included in the industrialized world further and further behind in lifestyle and potential for future development.