What are different techniques to remove pyrogenecity in vaccines, and recent work going on in this field?

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krishna-agrawala | College Teacher | (Level 3) Valedictorian

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Pyrogenecity refers to the quality or property of any drug to induce fever. Pyrogenetic drugs or vaccines induce fever because of presence of substances called pyrogens.

The vaccines can get contaminated with pyrogens during manufacture. Pyrogens may also be produced during growth and metabolism of certain micro organisms. Three methods are used for removing pyrogenecity in vaccines. These are:

  1. Removing pyrogens from vaccines.
  2. Deactivating pyrogens present in vaccines.
  3. Taking care during the manufacturing process that the vaccines are contaminated with pyrogens.