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Muscles must interact with the skeletal system, in very precise ways, for coordination of movements to occur effectively and these systems are regulated by the brain and spinal cord. The cerebrum in the brain controls conscious muscle movements such as picking up an item, walking, etc. When areas of the cerebrum are damaged as in a stroke, sometimes the ability to speak, walk or move may be diminished or lost because the cerebrum is where messages are sent to the muscles to carry out a voluntary activity. Balance and coordination are further regulated by the cerebellum, an area in the brain along with the fluid in the inner ear.
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