What are the consequences of man's disobedience in "Paradise Lost"?

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Man was cast out of the Garden of Eden and never allowed to return.In addition, the earth was cursed and man had to contend with "thorns and thistles" and endure hard labor in order to grow food to eat. Because access to the tree of life was prohibited, man eventually died. In addition, his wife suffered greater pain in childbirth and was put under the authority of her husband.

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