In this sonnet, Cullen is expressing some of his own pain against the lack of parity between the different elements of God's creation. He sets out by saying that he does not doubt that God means well—he is willing to give God the benefit of the doubt and assumes that God would be able to explain, if asked, why he has done some of the things he has done. For instance, he would be able to explain why he has chosen to make moles blind, or why humans have to die even though they are made in his image.
In lines 9–12, Cullen comes to the conclusion that God's ways are "inscrutable." So, even though undoubtedly God himself has a reason for the things he does, there is little point in humans trying to establish what these reasons may be. Cullen notes that we humans have minds to whose probing God's actions are "immune" because we are too preoccupied with the "petty cares" of our own existence to begin to comprehend what a being like God is thinking. The conclusion is, then, that Cullen accepts the wisdom of God, but has also accepted that it is a waste of time for him, a mere human, to try to understand it.
In the closing couplet of the poem, however, he expresses his own distress at the idea that God should have made a black poet "and bid him sing," suggesting that this is an unfairness in his own life which he wishes God could explain to him.