What are the causes of Victor Frankenstein's guilt in Frankenstein?
Interestingly enough, although the novel Frankenstein depicts the horror of existence for this abominable creature, Victor's guilt has nothing to do with the existential crisis through which he's put his monster and everything to do with the other humans he affects. Victor's first sign of guilt is upon hearing about the death of William and then the subsequent deaths of Justine, Henry, and Elizabeth at the hands of his creation.
It is an interesting choice, because it questions the nature of humanity and existence—what makes someone a person. Victor feels no guilt for the monster because he sees him...
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In Victor's creation and rejection of The Creature, The Creature turned to murdering all of Frankenstein's loved ones. The Creature strangled William (Victor's younger brother), Henry (Victor's best friend), Elizabeth (Victor's cousin/sister/lover), and set up Justine for the murder of William. Victor feels responsible for these horrific acts of The Creature. Therefore, Victor has an enormous amount of guilt.