An estimated 88,000 people die annually in the United States from alcohol-related deaths. This is the third leading cause of preventable death in the United States. In 2012, 3.3 million people died globally from alcohol. Additionally, the World Health Organization attributes more than 200 diseases and health conditions to alcohol consumption.
Smoking is the leading cause of preventable death. Almost a half million Americans die each year because of tobacco use and smoking. Globally, it causes a staggering seven million deaths each year. If smoking trends continue, approximately one out of every thirteen people alive today under age seventeen will die of a smoking-related disease.
Since marijuana usage has only been legalized recently and only in certain states, the statistics of usage attributing to death are not yet clear. While some will claim that marijuana doesn't kill people, it is clear that usage leads to impaired thinking, and this does kill people indirectly (such as impaired driving or a tendency toward suicidal thoughts in some people).
Because of recent growing trends in manufacturing opioids, it has become difficult to separate cocaine deaths from other opioid deaths. There does seem to be an upward trend in recent years of deaths to cocaine and opioid usage. Almost 2 percent of the American population uses cocaine, and in 2017, there were approximately 34,000 cocaine deaths. This represents a 34 percent increase from the previous year.