The 1972 novel Bless Me, Ultima, written by Rudolfo Anaya, takes place in New Mexico, which is also where Anaya is from. It's an important place to him (he calls it a "spiritual corridor") and to the characters in the novel. While you could look at the literal setting of the novel, I think there is a spiritual geography that is worth looking at, given that a major theme is the spiritual development of the protagonist. Ultima, a curandera (a kind of shaman or natural healer) comes to live with Antonio and his family and serves as his guide. The book exists in a very specific and detailed New Mexico, but it also exists in a supernatural dimension (the golden cod), in a religious (specifically Catholic) cosmology, which includes heaven, hell, purgatory, and a dream state. Antonio has many dreams throughout, all of which have symbolic importance and are part of his soul's journey.