In many of Shakespeare's tragedies, the topsy-turvy (things that are normal are normal no longer) aspect of nature takes place when something foul is about to happen. In the case of Julius Caesar,In Act I, Scene 3, prior to Caesar's assassination, a horrible storm surrounds the city and supernatural events also occur, such as ghosts walking and a slave whose hand catches fire yet is not burned. These events are an omen that something unnatural and out of man's hands are about to happen. This, indeed, is the case when Caesar's death seems preordained. He ignores the Soothsayer, his wife's, Calphurnia's, unnatural dreams, and Artemidorous, and meets his death.
Seemingly less obvious than the other three types of conflicts, man vs. himself, society, and man, man vs. nature plays a pivotal part in how Caesar is perceived by those around him. His lack of control over nature allows for the assimilation of his enemies into his "camp" so to speak. A good example of this is Caesar's supposed epilepsy. In Act 1, Caesar has a seizure in front of the community as well as his advisors. This can be seen as form of weakness although it is seemigly blown off by Cassius as Caesar's reaction to the crowd's "bad breath". Caesar will not be able to control this aspect of his life, the seizures are born out of nature and its inability to create perfect human beings.