What is amiodarone? How does it interact with other drugs?

Quick Answer
Drug used to restore normal heart rhythm.
Expert Answers
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Vitamin E

Effect: May Protect Against Side Effects

One of the problems with amiodarone is that it can cause injury to the lungs. One study suggests that vitamin E supplements might help prevent this side effect.

Chaparral, Comfrey, and Coltsfoot

Effect: Possible Harmful Interaction

The herbs chaparral (Larrea tridentata or L. mexicana), comfrey (Symphytum officinale), and coltsfoot (Tussilago farfara) contain liver-toxic substances. Because amiodarone can also affect the liver, combining these herbs with the medication is not advisable.

Dong Quai, St. John’s Wort

Effect: Possible Harmful Interaction

Amiodarone has been reported to cause increased sensitivity to the sun, amplifying the risk of sunburn or skin rash. Because St. John’s wort and dong quai may also cause this problem, taking these herbal supplements during amiodarone therapy might add to this risk. It may be a good idea to use sunscreen or wear protective clothing during sun exposure if taking one of these herbs while using amiodarone.


Kachel, D. L., et al. “Amiodarone-Induced Injury of Human Pulmonary Artery Endothelial Cells: Protection by Alpha-Tocopherol.” Journal of Pharmacology and Experimental Therapeutics 254 (1990): 1107-1112.