In my mind, it is. There are many similarities between the narrator and Hemingway: He himself was feeling guilty about all his wealth and well-being. As far as his wife is concerned, Hadley Richardson was rich indeed and contributed to his lavish lifestyle, which he wanted to carry out of his system; he thought it was responsible for his lost inspiration
I think it is virtually impossible to not compare Harry with Hemingway. Harry is both a writer and a lover of the hunt, and big-game hunting was certainly one of Hemingway's obsessions. Hemingway and his wife, Pauline, spent 10 weeks in East Africa on safari, and their experiences provided valuable information for several novels, as well as the short story, "The Short Happy Life of Francis Macomber." Hemingway contracted dysentery while there, no doubt the basis for Harry's deadly battle in The Snows of Kilimanjaro. According to eNotes' own introduction to the novel,
Many readers have seen Harry as a self-portrait of Hemingway himself. Reading the story this way, the reader can look into Hemingway’s struggles with himself: his insecurities, his machismo, his need and disdain for women. But it is not necessary to read the story through the lens of Hemingway’s biography.