In the Tempest Act V Scene I, what does Alonso mean when he says, "Irreparable is the loss, an patience Says it is past her cure"?

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In this quote, Alonso is referring to the loss of his son, Ferdinand (whom Alonso believes was drowned in the shipwreck). Alonso will never get his son back ("irreparable is the loss"). Alonso then personifies "patience" by stating that even having patience will not cure the feelings grief and loss he has in losing a son. His son will never return.

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