In Jonathon Edwards' sermon, "Sinners in the Hands of an Angry God", Edwards is basically saying that God is angry with all of mankind.
Based upon the Biblical quote from which his sermon was based upon, "their foot shall slide in due time" (Deuteronomy 32:35), Edwards was saying that no man was free from God's wrath. The sermon was meant to show his congregation that God is wrathful. The imagery shown in the sermon basically describes a horrifying picture of God ready to pull his hand out from under mankind and thus allow them to fall into the pits of Hell where the Devil is waiting.
Edwards left no man or woman out. His sermon was poignant in stating that God was angry with all. The imagery Edwards used in the poem was meant to elicit fear in the entire congregation.
Typically, this text is paired with Miller's play "The Crucible". The pairing allows readers to see how the hysteria broke out give the fear of God embraced by the Puritans.
He says God is angry with the sinners. In their time they called them the natural men. Natural men were people who didn't accept God into there hearts and didn't care.