Sickle cell disease is inherited. If a person is homozygous for sickle cell, they have the disease. If they are heterozygous for sickle cell, they have sickle cell trait. These people carriers but normally healthy.
Use a Punnett square to calculate the possible phenotypes and genotypes for the child of a normal homozygous mother and a father with sickle cell trait.
Using the information that was given in within the question, we are going to use the following allele representations:
S= sickle cell trait
s = normal
We are told that the father has the sickle cell trait. We will assume that the father is homozygous for sickle cell. Therefore,
Normal homozygous mom = ss
Homozygous sickle celled dad = SS
S Ss Ss
S Ss Ss
Thus, the probabilities of the genotype (allele combinations) and phenotype (physical appearance) frequencies of the F1 (offspring) generation would be:
Ss = 100%
100% Heterozygous carriers of sickle cell anemia.