I edited the question as I understood its meaning. The answer is yes, the sex of the reader/character can be of importance. "The Yellow Wallpaper" is a story that has quite often been used by feminists to illustrate the collapsing of fact and fiction. Below is a link to my answer explaining how Gilman used the story to argue for a different approach to depression or mental health for women. The story is very gender specific and based a particular view of a female nature. Since it is directly related to Gilman's experience as a women it may speak to different audiences differently ( this is not to say however that men should not read it or lack the capacity to understand it, quite to the contrary).