With so many responses, much is dependent on what individuals perceive and feel out of the quote. Bearing this in mind, I would make sure that there is some level of personal reflection in such a quote and that the answer you provide has some level of personal introspection. In my own mind, I think that the implication of the quote is that individuals need to keep themselves busy or occupied with the daily tasks that have to be done. In keeping ourselves busy, the quote presumes that our preoccupation with these elements prevent us from having to face the heart of loneliness that pervades our existence, who we are, and what we represent. The quote's underlying assumption is that there is a level of personal deception that seems to result from the daily work that is done, a concealment of the shrieking nothingness that haunts us. Whether or not this is true is more of personal reflection, but it seems like that this is where the quote is heading.