Of course, this sounds like a very straightforward commandment. So long as you don't kill anyone, you're fine. But you can conceive of it in ways that go beyond that.
For example, it can mean that you should not engage in behavior that could be dangerous to others. That might mean that you should not drink and drive. Even if you do not kill someone, you have acted in a way that could have led to killing someone. The same would go for texting while you drive.
You could even go farther than that and look at the choices you make as a consumer. You could say that you should not buy things made in conditions that harm workers. For example, if an electronic device is made in a factory with harsh conditions that have led to worker suicides, you could say that buying it is a form of violating this commandment.
In these ways, this commandment can apply to teens' lives much more than it would if you only think of it as a prohibition against actually killing someone.