Most of the poem reflects all of these things. First one should be aware that Ginsberg was Jewish; his friend and confidant Kerouac was Roman Catholic. One of their favorite places to go, before they started to travel around the world, was New York City - particularly Greenwich Village. In other works Ginsberg addresses the culture of San Francisco and Mexicali. Ginsberg also makes it clear that he is a homosexual and often finds himself in situations that he might not otherwise.
"I saw the best minds of my generation destroyed by madness, starving hysterical naked,dragging themselves through the negro streets at dawn looking for an angry fix, angelheaded hipsters burning for the ancient heavenly connection to the starry dynamo in the machinery of night"
"... who studied Plotinus Poe St. John of the Cross telepathy and bop kabbalah because the cosmos instinctively vibrated at their feet in Kansas, who loned it through the streets of Idaho seeking visionary indian angels who were visionary indian angels, who thought they were only mad when Baltimore gleamed in supernatural ecstasy, who jumped in limousines with the Chinaman of Oklahoma on the impulse of winter midnight streetlight smalltown rain, who lounged hungry and lonesome through Houston seeking jazz or sex or soup, and followed the brilliant Spaniard to converse about America and Eternity, a hopeless task, and so took ship to Africa"
You may also like to refer to all of Part 3 in which Ginsberg talks about his stint at Rockwell, a true occurrence.