In chapter 1 of Of Mice and Men, George outlines for Lennie their version of the American Dream:
Guys like us, that work on ranches, are the loneliest guys in the world. They got no family. They don't belong no place...With us it ain't like that. We got somebody to talk to that gives a damn about us...Someday--we're gonna get the jack together and we're gonna have a little house and a couple of acres an' a cow and some pigs and--An' live off the fatta the lan...(13-14).
Using Biblical imagery from Genesis ("Garden of Eden") and Exodus (the "Holy Land"), George juxtaposes the solitary existence of the migrant worker with he and Lennie's American Dream team. Whereas the other guys are alienated and alone, George and Lennie are a tandem who share their dreams.
This version of the Dream re-appears, sadly, at the end, just before George shoots Lennie. George will be really lonely then, but for now, in this Garden of Eden in the Salinas River Valley, George and Lennie have each other.
In the book Of Mice and Men there are all of the items listed. When I think of loneliness I think of Candy and Crooks, the Negro stable man. Crooks is not allowed to socialize with the others because he is a black man. He has to stay off by himself.
"Crooks, the Negro stable buck, had in bunk in a harness room; a little shed that leaned off the wall of the barn." (67)
Lennie wanders to Crooks room and Crooks at first is not happy about him being there.
"Why ain't you wanted ? Lennie asked." "Cause I'm black. They play cards in there, but I can't play because I'm black. They say I stink. "(68)
This is also a good example of Lennie's innocence because he has no idea why the others would shun Crooks.