"Ain't many guys travel around together … I don't know why. Maybe ever'body in the whole damn world is scared of each other" (Chapter 2).
Isolation and loneliness are key themes throughout the book. In many ways, they directly mirror an attitude that was likely prevalent during the Depression. Because of this, Lennie and George's relationship is at best, misunderstood, and at worst, highly suspicious.
In chapter two alone, the two are asked about traveling together on three occasions. In one, George is suspected of using Lennie for extra money. Another suggests the relationship is sexual. The quote above comes after George explains that he and Lennie look after one another. This final perspective, stated more as a question than a direct judgement, seems to sum up a pervasive sentiment of the times.