After becoming King, Macbeth slowly becomes more and more paranoid. He worries about the witches' prophesies for Banquo's sons. This is the point where he loses it completely. He orders the murder of his best friend and son. When only Banquo is killed and his son escapes, Macbeth goes to see the witches again to know his future. After hearing and seeing the apparitions, he goes after Macduff. His second warning was to "Beware the Thane of Fife." That is Macduff, so Macbeth has his killers murder Macduff's entire family. From the point of becoming king until he has Macduff's family killed, he is paranoid and controlling. He cannot lose his crown and he is willing to do anything to keep it. On top of that, his wife is slowly losing her mind (from her guilt) and he really shows no signs of caring for her health. He has the doctor do whatever it takes to make her better, but he never really has any connection with her after the ghost of Banquo appears throughout the rest of the play.