This is a great question. I think we can safely say that there were many things that Odysseus did not like and he had to undergo. From this perspective, we can say that the fates were against him. However, through perseverance, cunning, and some help from the gods, he managed to succeed. In light of this, let me give you two examples.
First, it took him 10 years to get back home from the end of the Trojan War. Part of the reason why it took him so long was on account of some gods who did not like him. They tossed him into the sea to fend for his life. Moreover, through his travels, he had to suffer greatly. However, he accepted his fate and work through it all with cunning and craft. For example, he escaped the Sirens, Cyclopes, Scylla, Circe, and many more.
Second, he had to overcome the suitors who were trying to gain the hand of Penelope in marriage. When he finally reached Ithaca, his home, he plotted his return and revenge. In the end, he defeated them through strategy and courage.