The first point to keep in mind is that Curley's wife is not given a name. This shows the marginalization of women in the book. Curley's wife is, therefore, understandably lonely and alienated from everyone on the ranch. She does not even love Curley. This is all the more surprising, because they are newly wed. According to the text, they have been married for only two weeks. Here is what Candy says:
Married two weeks and got the eye? Maybe that’s why Curley’s pants is full of ants.”
This quote also shows that Curley's wife dislikes Curley so much that she wants a relationship with another man. We do not know how true this is, but in the least she is not satisfied with being married to Curley. Moreover, she does cultivate a friendship with Lennie in the book.
Finally, we can't really blame Curley's wife. Curley is a cocky and arrogant character that no one on the farm likes or respects. The only reason why the men tolerate him is because he is boss's son.