The MD orders phenytoin 300 mg IVP stat. What is the rate of administration?
Information on drug label: Administer at a rate not to exceed 50mg over one minute.
I thought it would be 50 mg/minute but it was marked wrong! This one seems like it should be easy, but its confusing me.
I'm not sure if "rate of administration" means how many gtt/min or mg/min?
The answer was just marked wrong in general. I don't really have any further information. Do you think 50 mg/min should be correct?
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The administration guidelines of Phenytoin administration are given as (source:http://www.drugs.com/phenytoin.html)
"Do not exceed the infusion rate of 50 mg/min".
However, you also have to check the loading rate of drug, and for Phenytoin it is given as 10-15 mg/Kg. So, for a 70 kg patient, a loading of 15 mg/kg will take about 21 min.
the rate of administration is 50 mg/min and your answer should have been correct.
For cardiovascular patients, the recommended dosage is 25 mg/min to as low as 5-10 mg/min. (http://lifeinthefastlane.com/book/critical-care-drugs/phenytoin/).
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