Taking the four basic principles of McDonaldization, we could argue that the paradigm could proof effective in situations where quantity, and not quality is under scrutiny. Efficiency, calculability, predictability and control are four parameters which best apply to fields such as statistics, where data must be quantified and is answerable to a specific goal.
It is very hard to apply these into a household environment because the human dynamics that take place within a family are unpredictable and dependent on variables that surface in the everyday lives of individuals. Among these variables we have life-changing events of all kinds.
Surely, a home could be ran efficiently. It can also be predictable and calculable to a certain point assuming that the same exact events will flow identically from one day to another. However, the element of control is the part that is impossible monitor, as we cannot control human emotions, reactions, choices, or decisions.