In Into the Wild, what was Chris McCandless's biggest challenge?
On a pragmatic level, Chris Mccandless struggled with gaining the skills to survive on his own. His determination to live alone and far from the world of capitalism and greed that he abhorred was a way of rejecting his own participation in that system. But by avoiding having a community, Chris made certain he would have no one to turn to when he needed help. In the end, it was solitude that killed him, not only because having people around could have helped Chris avoid starvation but because other people could have helped him see he was being naive and stubbornly idealistic.
Despite being well...
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Chris McCandless faces several conflicts in the story. The first, and arguably largest is person vs. self. Chris is on a journey of self-discovery throughout the novel. He is constantly searching for what will bring him happiness and fulfillment in life, ultimately giving his life in the process.
But it can also be argued that Chris faces the challenge of person vs. society. It is clear from the back story Krakauer provides that Chris has had trouble fitting into his world since he was young. His sister, Carine remembers him spending much time alone as a child. He doesn't act in a way that would be considered average, in social terms. From spending his Friday nights feeding the homeless, to taking long solo journey's across country Chris struggled to find his place in society, and learn what it meant to be a part of a family for better or worse.
Lastly, and most obviously, Chris faced the conflict of man vs. nature. In the most literal sense Chris struggled to survive in Alaska (as well as the ocean and desert) by foraging, finding shelter, and hunting game. Ultimately this is the conflict that beat him.