In the 1930s, a chemical called DNP was prescribed as a weight loss pill. Describe how NDP is a metabolic poison and why it was thought to be a good mechanism for weight loss.
In 1933, Maurice Tainter, a clinical pharmacologist from Stanford University, found that the ingestion of 2-4-Dinitrophenol (DNP) resulted in huge weight loss. Shortly thereafter, it was promoted as a weight reduction medication and subsequently added in over-the-counter drugs and offered to the public with no need of a prescription.
The study of its pharmacologic characteristics indicated that it contained the ability to fuel metabolism to incredibly high levels without triggering major harm to vital organs and capacities. It was indicated to bring about weight reduction by uncoupling oxidative phosphorylation, resulting in both increased fat metabolism and metabolic rate
In contrast to thyroid hormone that was utilized for weight reduction, DNP did not affect nitrogen discharge and hence was hypothesized to cause fat as opposed to lean muscle loss. The subsequent surplus heat generation resulted in uncontrolled hyperthermia after collapse of thermoregulatory homeostasis, which leads to critical illness and mortality.
After a couple of years of its use, numerous harmful effects, including noxious hyperthermia, hepatotoxicity, growth of cataracts, and some instances of agranulocytosis were documented. As additional adverse symptoms were reported, DNP was banned and categorized as very dangerous and not fit for human ingestion by the Federal Drug Administration in 1938.
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