Given that English is a second (or third) language for you, sometimes unknown words will create a disconnect between a second language learner and the humor of the learned language because of the inability to understand the context of the word being used (even the word itself). Humor is based upon understanding the "ins and outs" of a language (slang never helps).
That said, while the narcissist comment is funny, I actually like the part about talking about things she doesn't know about. As pohnpei points out, people tend to try to come off far more educated than they actually are. The comedian admitting this is very funny (because she is poking fun at the people who tend to talk about things they know nothing about).