There are two components of Little’s condition. First of all, since she is nearly blind it is very difficult for her to read normal texts. She would need special large, blown-up texts. Most publishers have these available. In this way, she can follow along with the class.
The second component of Little’s condition is that she has difficulty fitting in with her classmates. Since she is different, it is easy for her to be ostracized. One way you could handle this in a classroom is to have kids put on special glasses that show things blurry the way that Little would see them. Once kits understand and have empathy for someone who is different, they are more likely to be inclusive.