The other answers to this question describe some notable similarities and differences between the Middle and New England Colonies. I will describe a few more below.
Although agriculture was more widely practiced in the fertile Middle Colonies than in New England, both regions also relied on manufacturing and commerce to fuel their economies. Large amounts of timber from the interior meant that shipbuilding was a major industry. Both regions also had valuable minerals, such as iron, for mining. Furthermore, both regions had deep-water ports that allowed for the establishment of successful trading hubs such as New York City, Baltimore, Philidelphia, Newport, and Boston.
The New England Colonies of Massachusetts, Rhode Island, and Connecticut were established with royal charters. In fact, there were no royal-charter colonies outside of New England. This means that they were relatively self-governing under the auspices of the English Crown. With the exception of New Hampshire, proprietary and royal colonies were only established outside of New England. Proprietary colonies included Pennsylvania, Maryland, and Delaware. As proprietary colonies, all land was owned and managed by a small group of elites and their governors reported directly to the king. The other Middle Colonies were royal colonies. Their governments were established directly by the Crown to directly fulfill the orders of the king. Therefore, they had much less autonomy.