How was Cushing's Syndrome discovered?I know it was discovered by Harvey Cushing but I'm not sure about anything else about it's discovery. Thanks!

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bullgatortail | High School Teacher | (Level 1) Distinguished Educator

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Dr. Harvey Cushing (1869-1939) published his first description of the disease for which his name was associated in 1912. Cushing's Syndrome is

an endocrinological syndrome caused by a malfunction of the pituitary gland which he (Cushing) termed "polyglandular syndrome."

Cushing first diagnosed the disease in a patient, "Minnie G.", in 1910 (or possibly earlier, since the information came from a lecture in December 1910). Minnie had many of the now common symptons, including hirsutism (extreme hairiness), loss of hair, obesity, florid bruising and a short stature. Cushing believed that she may have had the disorder for many years. Cushing "brilliantly speculated" that the disorder may have been related to hyperadrenalism, somewhat similar to Addison's disease. He later identified the disease in 47 other cases of "polyglandular syndrome."