Responses to government-imposed vaccinations will differ from government to government. Depending upon what nation is being referred to, how citizens of the nation react to the government imposing vaccinations will be different.
For example, in the United States of America, some may think that it is up to the individual whether or not a vaccination is necessary. These decisions can be based upon religious or personal ideologies.
In other countries, or nations, power over their citizens is very different. If the government decides to enforce specific vaccinations, the citizens will have no choice but to live by the rules and regulations the country deems necessary.
Some countries even require vaccinations of visitors. These countries will not allow entrance into their country unless the traveler can prove a specific vaccination has been received. (For example, if travelling to some countries in Africa and South America, one must have the Meningococcal vaccine.)
In the end, the way which a society reacts to mandatory vaccinations simply depends upon what individual rights are allocated and how the individual looks at the specific vaccination.