There are only two female characters of note in Hamlet: Gertrude, Hamlet’s mother, and Ophelia, Hamlet’s potential lover. In their own ways, both women betray Hamlet, and suffer dearly for their duplicity.
Gertrude is the first to betrayal Hamlet. Shortly after the death of her husband, King Hamlet, she remarried Claudius, King Hamlet’s brother and murderer. While at first she believes her son to be deranged, she eventually realizes her mistake and dies because of her misplaced trust in her new husband.
Ophelia, Hamlet’s supposed love, also betrays Hamlet. Instead of doing what her heart tells her, she allows herself to be dominated and manipulated by her father, thus losing Hamlet’s trust. Eventually, after Hamlet has killed her father, she completely loses touch with reality and drowns.