In Act Five, Scene 5, Macbeth learns that his wife has died and feels indifferent about her death. After receiving the news that Lady Macbeth is dead, Macbeth comments that the news of her death was bound to come eventually. Macbeth has given up hope and has become callous to the situation at hand. He speaks indifferently about death by saying,
"Life’s but a walking shadow, a poor player that struts and frets his hour upon the stage and then is heard no more. It is a tale told by an idiot, full of sound and fury, signifying nothing" (Shakespeare, 5.5.24-28).
Macbeth believes that life is nothing more than an illusion and compares his existence to a poor actor who hopelessly wanders around on a stage for a brief moment. Macbeth is extremely depressed and feels like life is absurd and pointless. He reflects on his unfortunate situation and determines that life is void of meaning. The death of his beloved wife, coupled with his guilt and mental agony, have left Macbeth feeling numb and indifferent. Macbeth has given up hope and does not care about life anymore in Act Five, Scene 5.