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From the very beginning of the scene, we can see that Lady Macbeth is very eager for her husband to gain accolades and power-- even if it means that he must commit murder. After she reads her husband's letter informing her of the Witches' prophecies, she states that while she is excited about the news, she doubts hs ability to follow through: "Thy nature... is too full o' the milk of kindness to catch the nearest way."
If her husband does not have the outright courage to do what "thou must do," Lady Macbeth is determined to drive out his fears and anything else that stands in the way of his attainment of the crown: "Hie thee hither, that I may pour my spirits in thine ear..."
Perhaps the most telling quote of all is when Lady Macbeth says, "Unsex me here..." She wishes that she could shed all entrapments of womanhood and femininity so that she could accomplish the feat of murder herself.
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